Microfluidic synthesis of α-ketoesters via oxidative coupling of acetophenones with alcohols under metal-free conditions-Reference-Cited by-同舟云学术

Microfluidic synthesis of α-ketoesters via oxidative coupling of acetophenones with alcohols under metal-free conditions

Published:2017 Issue:5 Volume:2 Page:650-655
ISSN:2058-9883
Container-title:React. Chem. Eng.
language:en
Short-container-title:React. Chem. Eng.

Author:

Guo Shiyu¹²³⁴,Dai Zhongxue¹²³⁴,Hua Jiawei¹²³⁴,Yang Zhao⁵⁶³⁴,Fang Zheng¹²³⁴,Guo Kai¹²³⁴⁷^ORCID

Affiliation:

1. College of Biotechnology and Pharmaceutical Engineering

2. Nanjing Tech University

3. Nanjing

4. China

5. College of Engineering

6. China Pharmaceutical University

7. State Key Laboratory of Materials-Oriented Chemical Engineering

Abstract

An efficient and novel method for the synthesis of α-ketoesters has been developed via oxidative coupling of acetophenones with alcohols under TBHP/I₂/DBU conditions in a microfluidic chip reactor, which has a wide substrate scope, uses a lower dosage of iodine and affords higher product yields in only a few seconds.

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RE/C7RE00107J

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