Molecular modeling of Plasmodium falciparum peptide deformylase and structure-based pharmacophore screening for inhibitors-Reference-Cited by-同舟云学术

Molecular modeling of Plasmodium falciparum peptide deformylase and structure-based pharmacophore screening for inhibitors

Published:2016 Issue:35 Volume:6 Page:29466-29485
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Manhas Anu¹²³⁴,Kumar Sivakumar Prasanth¹²³⁴^ORCID,Jha Prakash Chandra¹²³⁴

Affiliation:

1. School of Chemical Sciences

2. Central University of Gujarat

3. Gandhinagar-382030

4. India

Abstract

The role of metal coordination geometry and actinonin (inhibitor) binding was examined to develop pharmacophore-based inhibitor design strategy forPlasmodium falciparumpeptide deformylase.

Funder

University Grants Commission

Department of Biotechnology , Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA01071G

Reference68 articles.

1. Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents

2. World Health Organization , Deaths by cause, sex and mortality stratum in WHO regions, estimates for 2001, World Health Report, Geneva, 2002

3. Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

4. Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation.

5. Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms

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