Enterobactin- and salmochelin-β-lactam conjugates induce cell morphologies consistent with inhibition of penicillin-binding proteins in uropathogenic Escherichia coli CFT073-Reference-Cited by-同舟云学术

Enterobactin- and salmochelin-β-lactam conjugates induce cell morphologies consistent with inhibition of penicillin-binding proteins in uropathogenic Escherichia coli CFT073

Published:2021 Issue:11 Volume:12 Page:4041-4056
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sargun Artur¹²³⁴^ORCID,Johnstone Timothy C.¹²³⁴^ORCID,Zhi Hui⁵⁶⁷⁸⁴,Raffatellu Manuela⁵⁶⁷⁸⁴^ORCID,Nolan Elizabeth M.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Massachusetts Institute of Technology

3. Cambridge

4. USA

5. Division of Host-Microbe Systems and Therapeutics

6. Department of Pediatrics

7. University of California San Diego

8. La Jolla

Abstract

Siderophore-β-lactam conjugates based on enterobactin and diglucosylated enterobactin enter the periplasm of uropathogenic E. coli CFT073 via the FepA and IroN transporters, and target penicillin-binding proteins.

Funder

National Institutes of Health

University of California, San Diego

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC04337K

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