Heck reaction synthesis of anthracene and naphthalene derivatives as traps and clean chemical sources of singlet molecular oxygen in biological systems

Author:

Oliveira Marilene Silva12345ORCID,Chorociejus Gabriel12345ORCID,Angeli José Pedro F.6789ORCID,Vila Verde Giuliana1011125ORCID,Aquino Gilberto L. B.1011125ORCID,Ronsein Graziella E.12345ORCID,Oliveira Maurício César Bof de131445ORCID,Barbosa Livea F.12345ORCID,Medeiros Marisa H. G.12345ORCID,Greer Alexander1516171819ORCID,Di Mascio Paolo12345ORCID

Affiliation:

1. Departamento de Bioquímica

2. Instituto de Química

3. Universidade de São Paulo

4. São Paulo

5. Brazil

6. Rudolf Virchow Center for Translational Bioimaging

7. University of Würzburg

8. 97080 Würzburg

9. Germany

10. Campus Anápolis de Ciências Exatas e Tecnológicas Henrique Santillo

11. Universidade Estadual de Goiás

12. 75001-970 Anápolis

13. Setor Técnico-Científico

14. Polícia Federal

15. Department of Chemistry

16. Brooklyn College

17. City University of New York

18. Brooklyn

19. USA

Abstract

Our study shows that new anthracene and naphthalene derivatives function as compounds for trapping and chemically generating singlet molecular oxygen [O2(1Δg)], respectively. The syntheses of these derivatives are described, as well as some localization testing in cells.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Pro-Reitoria de Pesquisa, Universidade de São Paulo

John Simon Guggenheim Memorial Foundation

National Science Foundation

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

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