An immuno-potentiating vehicle made of mesoporous silica-zinc oxide micro-rosettes with enhanced doxorubicin loading for combined chemoimmunotherapy

Author:

Qian Guowen12345,Wang Xiupeng456ORCID,Li Xia456,Ito Atsuo456,Sogo Yu456,Ye Jiandong12378ORCID

Affiliation:

1. School of Materials Science and Engineering, South China University of Technology

2. Guangzhou 510641

3. China

4. Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST)

5. Tsukuba

6. Japan

7. National Engineering Research Centre for Tissue Restoration and Reconstruction

8. Guangzhou

Abstract

MS-Zn-DOX in combination with PIC not only significantly inhibit tumor growth, but also effectively rejects tumor metastasis in vivo, obviously improving CD4+ and CD8+ T cell populations and IFN-γ secretion in splenocytes of mice.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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