Inhibitor and substrate cooperate to inhibit amyloid fibril elongation of α-synuclein-Reference-Cited by-同舟云学术

Inhibitor and substrate cooperate to inhibit amyloid fibril elongation of α-synuclein

Published:2020 Issue:41 Volume:11 Page:11331-11337
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Agerschou Emil Dandanell¹²³⁴,Borgmann Vera¹²³⁴,Wördehoff Michael M.¹²³⁴^ORCID,Hoyer Wolfgang¹²³⁴⁵^ORCID

Affiliation:

1. Institut für Physikalische Biologie

2. Heinrich-Heine-Universität Düsseldorf

3. 40225 Düsseldorf

4. Germany

5. Institute of Biological Information Processing, Structural Biochemistry (IBI-7)

Abstract

Amyloid fibril elongation of α-synuclein can be described with the Michaelis–Menten model, where α-synuclein monomer plays a dual role by serving as growth substrate as well as supporting the competitive inhibitor CC48 in blocking fibril ends.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC04051G

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