Enzymatic synthesis of natural (+)-aristolochene from a non-natural substrate-Reference-Cited by-同舟云学术

Enzymatic synthesis of natural (+)-aristolochene from a non-natural substrate

Published:2016 Issue:97 Volume:52 Page:14027-14030
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Faraldos Juan A.¹²³⁴,Grundy Daniel J.¹²³⁴,Cascon Oscar¹²³⁴,Leoni Stefano¹²³⁴,van der Kamp Marc W.⁵⁶¹⁷⁸^ORCID,Allemann Rudolf K.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. Cardiff University

3. Cardiff CF10 3AT

4. UK

5. School of Biochemistry

6. Faculty of Biomedical Sciences & Centre for Computational Chemistry

7. University of Bristol

8. Biomedical Sciences Building

Abstract

Aristolochene synthase from Penicillium roqueforti converts 7-methylene-FDP, a substrate the enzyme never encounters in nature, to the natural product (+)-aristolochene.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC08164A

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4. Structural Biology and Chemistry of the Terpenoid Cyclases

5. Sesquiterpene synthases: Passive catalysts or active players?

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