Dimethyl sulfoxide as a mild oxidant in S–P(O) bond construction: simple and metal-free approaches to phosphinothioates

Author:

Sun Jian-Guo1234,Weng Wei-Zhi1234,Li Ping1234,Zhang Bo1234ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines

2. China Pharmaceutical University

3. Nanjing 210009

4. China

Abstract

A direct metal-free oxidative S–P(O) coupling reaction for the preparation of phosphinothioates starting with readily available thiols (or disulfides) and P(O)H compounds using DMSO as a mild oxidant is presented.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Reference54 articles.

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4. N. N. Melnikov , Chemistry of Pesticides, Springer-Verlag, New York, 1971

5. Synthesis, Properties, and Applications of Oligonucleotides Containing an RNA Dinucleotide Phosphorothiolate Linkage

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