Synthesis of 4-phenyl-5,6-dihydrobenzo[h]quinazolines and their evaluation as growth inhibitors of carcinoma cells

Author:

Maurya Hardesh K.1234ORCID,Hasanain Mohammad5674,Singh Sarita1234,Sarkar Jayanta5674,Dubey Vijaya8234,Shukla Aparna9234,Luqman Suaib8234,Khan Feroz9234,Gupta Atul1234

Affiliation:

1. Medicinal Chemistry Department

2. CSIR-Central Institute of Medicinal and Aromatic Plants

3. Lucknow 226015

4. India

5. Division of Biochemistry

6. CSIR-Central Drug Research Institute

7. Lucknow 226 031

8. Molecular Bioprospection Department

9. Metabolic Structural Biology Department

Abstract

The synthesis of various benzo[h]quinazoline analogs was accomplished through the reaction of chalcone with guanidine. The synthesized compounds were screened for their anticancer potential against different cancer cells.

Funder

Council for Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference27 articles.

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2. Cancer statistics, 2014

3. http://www.who.int/mediacentre/factsheets/fs297/en/:Fact sheet N°297

4. Targeting the Estrogen Receptor using Steroid–Therapeutic Drug Conjugates (Hybrids)

5. Fulvestrant

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