Total synthesis of the natural (−)-205B alkaloid and its activity toward α7 nAChRs-Reference-Cited by-同舟云学术

Total synthesis of the natural (−)-205B alkaloid and its activity toward α7 nAChRs

Published:2023 Issue:4 Volume:21 Page:817-822
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mazeh Sara¹^ORCID,Garcia-Fernandez M. Dolores²,Pelletier Barbara²,Moreau Christophe²,Delair Philippe¹^ORCID

Affiliation:

1. Départment de Pharmacochimie Moléculaire, Univ. Grenoble Alpes, ICMG FR-2607, CNRS, UMR-5063, F-38041, Grenoble, France

2. Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France

Abstract

Highly stereoselective synthesis of the (−)-205B alkaloid has been performed from intermediate 3b which was easily prepared from a commercially available chiral secondary alcohol. The behaviour of this alkaloid toward the α7 nicotinic receptor was determined.

Funder

Agence Nationale de la Recherche

Université Grenoble Alpes

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB01723G

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