Activity and conformation of lysozyme in molecular solvents, protic ionic liquids (PILs) and salt

Activity and conformation of lysozyme in molecular solvents, protic ionic liquids (PILs) and salt–water systems

Published:2016 Issue:37 Volume:18 Page:25926-25936
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Wijaya Emmy C.¹²³⁴⁵,Separovic Frances¹²³⁴^ORCID,Drummond Calum J.⁶⁷⁸⁹⁴,Greaves Tamar L.⁶⁷⁸⁹⁴

Affiliation:

1. School of Chemistry

2. Bio21 Institute

3. The University of Melbourne

4. Australia

5. CSIRO Manufacturing

6. School of Science

7. College of Science

8. Engineering and Health

9. RMIT University

Abstract

The role of solvent features on enzyme stability was investigated by comparing the conformation and activity of lysozyme in molecular solvents, PILs and salt solutions. Electrostatic interactions and the solvophobic effect dominated at low and high solvent concentrations, respectively.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C6CP03334B

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