The iron regulatory proteins are defective in repressing translation via exogenous 5′ iron responsive elements despite their relative abundance in leukemic cellular models-Reference-Cited by-同舟云学术

The iron regulatory proteins are defective in repressing translation via exogenous 5′ iron responsive elements despite their relative abundance in leukemic cellular models

Published:2018 Issue:4 Volume:10 Page:639-649
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Pourcelot Emmanuel¹²³⁴⁵,Lénon Marine¹²³⁴⁵,Charbonnier Peggy⁶⁵,Louis Fiona⁶⁵^ORCID,Mossuz Pascal⁷⁸⁹¹⁰⁵,Moulis Jean-Marc¹²³⁴⁵^ORCID

Affiliation:

1. Univ. Grenoble Alpes

2. Inserm U1055

3. Laboratory of Fundamental and Applied Bioenergetics (LBFA) and SFR BEeSy

4. 38000 Grenoble

5. France

6. Commissariat à l'Energie Atomique et aux Energies Alternatives – Biosciences & Biotechnology Institute of Grenoble (BIG)

7. CHU Grenoble

8. Laboratoire d’ Hématologie

9. Institut de Biologie et Pathologie

10. Grenoble

Abstract

Endogenous IRP outnumbers IRE-containing mRNA but fails to bind to transfected exogenous ones.

Funder

Novartis

Université Joseph Fourier

Ligue Contre le Cancer

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MT/C8MT00006A

Reference52 articles.

1. Molecular mechanisms of translational control

2. Regulation of cellular iron metabolism

3. Iron Regulatory Proteins: From Molecular Mechanisms to Drug Development

4. The functional duality of iron regulatory protein 1

5. Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

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