3D stem cell spheroids with urchin-like hydroxyapatite microparticles enhance osteogenesis of stem cells

Author:

Liu Hongmei1,Ye Jianxin2,Hu Hui1,Song Yuheng1,Qiang Huijun1,Wang Junjun1,Zhou Lei2,Wang Xuefen1ORCID,Fei Xiang13ORCID,Zhu Meifang1ORCID

Affiliation:

1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China

2. Department of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China

3. Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, China

Abstract

E-uHA, an urchin-like hydroxyapatite using glutamic acid (E) as a co-template, is integrated with BMSCs via handing drop for spheroids with a low concentration, showing high cell viability, cell migration activity and excellent osteogenic potential.

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

National Key Research and Development Program of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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