Tamoxifen-like metallocifens target the thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells-Reference-Cited by-同舟云学术

Tamoxifen-like metallocifens target the thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells

Published:2017 Issue:7 Volume:9 Page:949-959
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Scalcon Valeria¹²³,Salmain Michèle⁴⁵⁶⁷⁸^ORCID,Folda Alessandra¹²³,Top Siden⁴⁵⁶⁷⁸^ORCID,Pigeon Pascal⁴⁵⁶⁷⁸^ORCID,Shirley Lee Hui Zhi⁴⁵⁶⁷⁸,Jaouen Gérard⁴⁵⁶⁷⁸^ORCID,Bindoli Alberto⁹¹⁰¹¹³,Vessières Anne⁴⁵⁶⁷⁸^ORCID,Rigobello Maria Pia¹²³^ORCID

Affiliation:

1. Dipartimento di Scienze Biomediche

2. Università di Padova

3. Italy

4. Sorbonne Universités

5. UPMC Univ Paris 06

6. CNRS

7. Institut Parisien de Chimie Moléculaire (IPCM)

8. F-75005 Paris

9. Istituto di Neuroscienze (CNR) Sezione di Padova

10. c/o Dipartimento di Scienze Biomediche

11. 35131 Padova

Abstract

Metallocifens of Fe, Os and Ru derived from tamoxifen target mitochondria, inhibit the thioredoxin system, determine ROS increase and collapse of the mitochondrial membrane potential triggering cell death.

Funder

European Cooperation in Science and Technology

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MT/C7MT00121E

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