Design, synthesis, <i>in silico</i> studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers-Reference-Cited by-同舟云学术

Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers

Published:2023 Issue:32 Volume:13 Page:22122-22147
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Saleh Abdulrahman M.¹²^ORCID,Mahdy Hazem A.¹^ORCID,El-Zahabi Mohamed Ayman¹,Mehany Ahmed B. M.²,Khalifa Mohamed M.¹^ORCID,Eissa Ibrahim H.¹^ORCID

Affiliation:

1. Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

2. Zoology Department, Faculty of Science (Boys), Al-Azhar University, Cairo 11884, Egypt

Abstract

A novel series of pyrimidine-5-carbonitrile derivatives bearing benzylidene and hydrazone moieties with different linkers (spacers) were designed and synthesized as possible inhibitors of the vascular endothelial growth factor receptor-2 (VEGFR-2).

Funder

Science and Technology Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA04182D

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