A cationic lipid with advanced membrane fusion performance for pDNA and mRNA delivery

Author:

Wei Yu1,He Ting1,Bi Qunjie1,Yang Huan1,Hu Xueyi1,Jin Rongrong1ORCID,Liang Hong23,Zhu Yongqun4,Tong Rongsheng23,Nie Yu1ORCID

Affiliation:

1. National Engineering Research Center for Biomaterials/College of Biomedical Engineering, Sichuan University, Chengdu 610064, China

2. Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China

3. Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China

4. Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou 310058, China

Abstract

Cationic lipids were designed to study the structure–activity relationship of hydrophobic parts. At a certain length, the unsaturation degrees significantly affected the transgene expression through enhancing membrane fusion and fluidity.

Funder

Sichuan Provincial Postdoctoral Science Foundation

National Natural Science Foundation of China

Chinesisch-Deutsche Zentrum für Wissenschaftsförderung

Chengdu Science and Technology Bureau

Sichuan Province Science and Technology Support Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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