Precise delivery of a multifunctional nanosystem for MRI-guided cancer therapy and monitoring of tumor response by functional diffusion-weighted MRI

Author:

Xiao Zeyu1234,Chan Leung5634,Zhang Dong1234,Huang Cuiqing1234,Mei Chaoming5634,Gao Peng1234,Huang Yanyu5634,Liang Jianye1234,He Lizhen5634,Shi Changzheng12347,Chen Tianfeng5634ORCID,Luo Liangping1234

Affiliation:

1. Medical Imaging Center

2. First Affiliated Hospital of Jinan University

3. Guangzhou

4. P. R. China

5. Department of Chemistry

6. Jinan University

7. Department of Radiology

Abstract

Herein we synthesize a cRGD peptide-conjugated PLGA nanosystem which is a high-efficiency drug-delivery platform for MR imaging-guided cancer theranostics.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference47 articles.

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2. Global cancer statistics, 2012

3. Doxil® — The first FDA-approved nano-drug: Lessons learned

4. Doxorubicin Hydrochloride for Injection, USP, https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/050467s070lbl.pdf

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