Nonpeptide small molecules with a ten-membered macrolactam or a morpholine motif from the insect American cockroach and their antiangiogenic activity

Author:

Yan Yong-Ming1234,Meng Xiao-Hui1234,Bai Hong-Fu1234,Cheng Yong-Xian1234ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Shenzhen University Health Science Center

3. Shenzhen

4. P.R. China

Abstract

(±)-Periplactam A (1), a rare ten-membered macrolactam composed of lignan and putrescine, (±)-periplanol E (2), a dimeric phenethyl alcohol derivative formed via morpholine, and periplactams B (3) and C (4) were isolated from American cockroach.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

National Science Fund for Distinguished Young Scholars

Shenzhen Fundamental Research Program

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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