Organocatalytic enantio- and diastereoselective assembly of cyclopropane-incorporated polycyclic molecules via isobenzopyrylium ions

Author:

Liu Shuxuan12,Zhang Chaoshen2ORCID,Han Zhengyu1,Huang Hai1ORCID,Sun Jianwei2ORCID

Affiliation:

1. Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, China

2. Department of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China

Abstract

An organocatalytic asymmetric cycloaddition of isobenzopyrylium with vinylboronic acid was successfully developed, providing rapid access to cyclopropane-containing complex polycyclic structures with four chiral centers.

Funder

National Natural Science Foundation of China

Innovation and Technology Commission

Publisher

Royal Society of Chemistry (RSC)

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