Is interaction of amyloid β-peptides with metals involved in cognitive activity?-Reference-Cited by-同舟云学术

Is interaction of amyloid β-peptides with metals involved in cognitive activity?

Published:2015 Issue:8 Volume:7 Page:1205-1212
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Tamano Haruna¹²³⁴,Takeda Atsushi¹²³⁴

Affiliation:

1. Department of Neurophysiology

2. School of Pharmaceutical Sciences

3. University of Shizuoka

4. Suruga-ku, Japan

Abstract

Metal ions,i.e., Zn²⁺and Cu²⁺, are released from neuron terminals in the hippocampus, which plays important roles in spatial and declarative memory, and may serve as a signal factor. Aβ is bound to Zn²⁺and Cu²⁺in the extracellular compartment and forms oligomers, potentially followed by transiently cognitive decline.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MT/C5MT00076A

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