Subcellular localization and therapeutic efficacy of polymeric micellar nanoparticles encapsulating bedaquiline for tuberculosis treatment in zebrafish-Reference-Cited by-同舟云学术

Subcellular localization and therapeutic efficacy of polymeric micellar nanoparticles encapsulating bedaquiline for tuberculosis treatment in zebrafish

Published:2023 Issue:6 Volume:11 Page:2103-2114
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Bhandari Madhavi¹,Soria-Carrera Héctor²³⁴^ORCID,Wohlmann Jens¹,Dal Nils-Jørgen Knudsen¹,de la Fuente Jesús M.²³,Martín-Rapún Rafael²³⁴^ORCID,Griffiths Gareth¹,Fenaroli Federico¹⁵^ORCID

Affiliation:

1. Department of Biosciences, University of Oslo, Blindernveien 31, 0371 Oslo, Norway

2. Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, C/Mariano Esquillor s/n, 50018 Zaragoza, Spain

3. CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029 Madrid, Spain

4. Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Zaragoza, c/Pedro Cerbuna 12, 50009 Zaragoza, Spain

5. Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, 4021 Stavanger, Norway

Abstract

Polymeric nanoparticles containing Bedaquiline reduce bacterial burden and improve survival in Mycobacterium marinum infected zebrafish. The nanoparticles accumulate in tuberculosis granulomas and in endothelial cells ending up in late endosomes.

Funder

Consejo Superior de Investigaciones Científicas

Ministerio de Ciencia e Innovación

Norges Forskningsråd

Gobierno de Aragón

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM01835G

Reference44 articles.