Highly functionalized pyrrolidine analogues: stereoselective synthesis and caspase-dependent apoptotic activity-Reference-Cited by-同舟云学术

Highly functionalized pyrrolidine analogues: stereoselective synthesis and caspase-dependent apoptotic activity

Published:2018 Issue:72 Volume:8 Page:41226-41236
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kumar Raju Suresh¹²³⁴⁵^ORCID,Almansour Abdulrahman I.¹²³⁴⁵,Arumugam Natarajan¹²³⁴⁵^ORCID,Mohammad Faruq⁶¹²³⁴^ORCID,Alshahrani Waleed Shihan¹²³⁴⁵,D Kotresha⁷⁸⁹¹⁰,Altaf Mohammad¹²³⁴⁵,Azam Mohammad¹²³⁴⁵,Menéndez J. Carlos¹¹¹²¹³¹⁴¹⁵^ORCID

Affiliation:

1. Department of Chemistry

2. College of Science

3. King Saud University

4. Riyadh 11451

5. Saudi Arabia

6. Surfactant Research Chair

7. Department of Microbiology

8. East West Group of Institution

9. Bangaluru-560091

10. India

11. Unidad de Química Orgánica y Farmacéutica

12. Departamento de Química en Ciencias Farmacéuticas

13. Facultad de Farmacia

14. Universidad Complutense

15. 28040 Madrid

Abstract

Spiropyrrolidines were synthesized employing a new class of azomethine ylide for the first time and were tested for their anticancer activity, where the cell death mechanism revealed that it is occurring through the caspase-3 dependent pathway.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA07985D

Reference57 articles.

1. Multitarget drugs: the present and the future of cancer therapy

2. R. J.Monlineux , in Alkaloids: Chemical and Biological Perspectives , ed. S. W. Pelletier , Wiley , New York , 1987 , ch. 1

3. Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids