A one-pot stepwise approach to axially chiral quinoline-3-carbaldehydes enabled by iminium–allenamine cascade catalysis-Reference-Cited by-同舟云学术

A one-pot stepwise approach to axially chiral quinoline-3-carbaldehydes enabled by iminium–allenamine cascade catalysis

Published:2021 Issue:3 Volume:8 Page:605-612
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Shao You-Dong¹²³,Han Dan-Dan¹²³,Dong Meng-Meng¹²³,Yang Xin-Ru¹²³,Cheng Dao-Juan⁴⁵³¹²^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering

2. Heze University

3. China

4. School of Pharmacy

5. Anhui University of Chinese Medicine

Abstract

An organocatalytic atroposelective annulation between 2-(tosylamino)aryl ketones and 2-alkynals for the construction of enantioenriched axially chiral 4-arylquinoline-3-carbaldehydes is achieved.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01339K

Reference92 articles.

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2. The Challenge of Atropisomerism in Drug Discovery

3. A twist of nature – the significance of atropisomers in biological systems

4. Revealing Atropisomer Axial Chirality in Drug Discovery

5. Atropisomerism in medicinal chemistry: challenges and opportunities

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