Synthesis and biological evaluation of 5-chalcogenyl-benzo[h]quinolines via photocyclization of arylethynylpyridine derivatives

Author:

Peglow Thiago J.1,Martins Carolina C.2,da Motta Ketlyn P.2,Luchese Cristiane2,Wilhelm Ethel A.2ORCID,Stieler Rafael1,Schneider Paulo H.1ORCID

Affiliation:

1. Instituto de Química, Laboratory of Molecular Catalysis (LAMOCA), Universidade Federal do Rio Grande do Sul (UFRGS), 91501-970, Porto Alegre-RS, P.O. Box 15003, Brazil

2. Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas (UFPel), 96010-900, Pelotas-RS, Brazil

Abstract

A new method for the synthesis of benzo[h]quinolines 5-chalcogenyl-functionalized via visible light-promoted intramolecular ortho-cyclization was described. Furthermore, studies have suggested that this class of compounds may have promising therapeutic potential.

Funder

Instituto Nacional de Ciência e Tecnologia de Catálise em Sistemas Moleculares e Nanoestruturados

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference80 articles.

1. L. D.Quin , Fundamentals of Heterocyclic Chemistry , Wiley-VCH , Weinheim, Germany , 2010

2. A Review on Medicinally Important Heterocyclic Compounds

3. Heterocycles in Medicinal Chemistry

4. Heterocycles in drugs and drug discovery

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