Salts of rucaparib with dicarboxylic acids: synthesis, crystal structures and solubility-Reference-Cited by-同舟云学术

Salts of rucaparib with dicarboxylic acids: synthesis, crystal structures and solubility

Published:2022 Issue:44 Volume:24 Page:7813-7820
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Wu Chao¹,Gao Lu¹,Xiong Jing²,Dai Xia-Lin¹^ORCID,Gao Wei³,Lu Tong-Bu⁴^ORCID,Chen Jia-Mei¹^ORCID

Affiliation:

1. Tianjin Key Laboratory of Drug Targeting and Bioimaging, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China

2. National Institutes for Food and Drug Control, Beijing 102629, China

3. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China

4. Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China

Abstract

Three new salts of rucaparib with fumaric acid, adipic acid and pimelic acid were synthesized and characterized, and the latter two demonstrate significantly improved solubility without sacrificing hygroscopicity and physical stability.

Funder

National Natural Science Foundation of China

Guangdong Pharmaceutical University

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CE/D2CE00842D

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