Microfluidic production of nanogels as alternative triple transfection reagents for the manufacture of adeno-associated virus vectors-Reference-Cited by-同舟云学术

Microfluidic production of nanogels as alternative triple transfection reagents for the manufacture of adeno-associated virus vectors

Published:2023 Issue:12 Volume:15 Page:5865-5876
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Whiteley Zoe¹,Massaro Giulia²,Gkogkos Georgios³^ORCID,Gavriilidis Asterios³^ORCID,Waddington Simon N.⁴⁵,Rahim Ahad A.²,Craig Duncan Q. M.¹^ORCID

Affiliation:

1. Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK

2. Department of Pharmacology, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK

3. Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK

4. Institute for Women's Health, University College London, 84-84 Chenies Mews, London, WC1E 6HU, UK

5. MRC Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witswatersrand, Johannesburg, South Africa

Abstract

Microfluidic produced nanogels provide an alternative to standard transfection reagents for the manufacture of adeno-associated viral vectors (AAVs), with equivelant viral titres demonstrated.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D2NR06401D

Reference53 articles.

1. M.Agbandje-McKenna and J.Kleinschmidt , in Adeno-Associated Virus Methods and Protocols , 2011 , vol. 807 , pp. 47–92

2. Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye

3. Recent Progress in European Advanced Therapy Medicinal Products and Beyond

4. Onasemnogene abeparvovec. AAV vector-based gene-replacement therapy, Treatment of spinal muscular atrophy

5. D. J. A.Crommelin , R. D.Sindelar and B.Meibohm , Pharmaceutical biotechnology: Fundamentals and applications , 2019 , pp. 57–82

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