Design of an activatable NIR-II nanoprobe for the <i>in vivo</i> elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations-Reference-Cited by-同舟云学术

Design of an activatable NIR-II nanoprobe for the in vivo elucidation of Alzheimer's disease-related variations in methylglyoxal concentrations

Published:2022 Issue:42 Volume:13 Page:12511-12518
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lai Yi¹,Dang Yijing¹,Sun Qian¹,Pan Jiaxing²,Yu Haijun²^ORCID,Zhang Wen¹^ORCID,Xu Zhiai¹^ORCID

Affiliation:

1. School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China

2. State Key Laboratory of Drug Research, Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China

Abstract

A biocompatible Fe3O4 nanoparticle integrating methylglyoxal-activatable NIR-II fluorescent probe and brain-targeting peptide was developed for visualizing Alzheimer's disease (AD)-related methylglyoxal variation in vivo.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC05242C

Reference27 articles.

1. Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

2. Advances in Alzheimer’s Diagnosis and Therapy: The Implications of Nanotechnology