The catalytic reaction mechanism of tyrosylprotein sulfotransferase-1-Reference-Cited by-同舟云学术

The catalytic reaction mechanism of tyrosylprotein sulfotransferase-1

Published:2021 Issue:41 Volume:23 Page:23850-23860
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Šmak Pavel¹^ORCID,Tvaroška Igor¹²^ORCID,Koča Jaroslav¹³

Affiliation:

1. National Center for Biomolecular Research (NCBR), Faculty of Science, Masaryk University, Brno, Czech Republic

2. Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovak Republic

3. Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic

Abstract

The reaction mechanism of TPST-1 was examined using two QM/MM methods: ab initio CPMD metadynamics and potential energy scan. The results support the SN2 reaction mechanism and show the role of the different amino acids in the catalytic mechanism.

Funder

Ministerstvo Školství, Mládeže a Tělovýchovy

Slovenská Akadémia Vied

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP03718H

Reference66 articles.

1. Tyrosine sulfation: a modulator of extracellular protein–protein interactions

2. Strategies for drug discovery by targeting sulfation pathways

3. Tyrosine sulfation: an increasingly recognised post-translational modification of secreted proteins

4. The Biology and Enzymology of Protein Tyrosine O-Sulfation

5. Selectins—The Two Dr. Jekyll and Mr. Hyde Faces of Adhesion Molecules—A Review

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Crystal structure of tick tyrosylprotein sulfotransferase reveals the activation mechanism of the tick anticoagulant protein madanin;Journal of Biological Chemistry;2024-03

2. Association between plasma proteome and glioma: A two-sample Mendelian randomization analysis;2023-07-25

3. A prognostic model based on clusters of molecules related to epithelial–mesenchymal transition for idiopathic pulmonary fibrosis;Frontiers in Genetics;2023-01-06