Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and <i>in vivo</i> efficacy-Reference-Cited by-同舟云学术

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy

Published:2022 Issue:12 Volume:13 Page:3563-3570
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Al Ayed Karol¹,Ballantine Ross D.²,Hoekstra Michael¹,Bann Samantha J.²,Wesseling Charlotte M. J.¹,Bakker Alexander T.³,Zhong Zheng⁴^ORCID,Li Yong-Xin⁴,Brüchle Nora C.¹,van der Stelt Mario³,Cochrane Stephen A.²^ORCID,Martin Nathaniel I.¹^ORCID

Affiliation:

1. Biological Chemistry Group, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands

2. School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, BT9 5AG, Belfast, UK

3. Molecular Physiology Group, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

4. Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China

Abstract

Convenient solid-phase approaches are described for the synthesis of brevicidine and laterocidine. Also reported are novel analogues including a laterocidine variant with enhanced hydrolytic stability and potent in vivo antibacterial activity.

Funder

Engineering and Physical Sciences Research Council

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC00143H

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5. https://www.who.int/news-room/detail/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed

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