Anti-myeloma pro-apoptotic Pt(ii) diiodido complexes

Author:

Masaryk Lukáš1ORCID,Weiser Drozdková Denisa23ORCID,Słoczyńska Karolina4ORCID,Moncol’ Ján5ORCID,Milde David6ORCID,Křikavová Radka1ORCID,Popiół Justyna4ORCID,Pękala Elżbieta4,Ondrušková Katarína2,Nemec Ivan17ORCID,Smešný Trtková Kateřina238ORCID,Štarha Pavel1ORCID

Affiliation:

1. Department of Inorganic Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic

2. Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 77515 Olomouc, Czech Republic

3. Institute of Molecular and Clinical Pathology and Medical Genetics, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Vítkovice, Czech Republic

4. Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland

5. Department of Inorganic Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, 81237 Bratislava, Slovakia

6. Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic

7. Central European Institute of Technology, Brno University of Technology, Purkyňova 123, 61200 Brno, Czech Republic

8. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 5, 77515 Olomouc, Czech Republic

Abstract

Highly anti-myeloma effective, DNA non-binding diiodidoplatinum(ii) complexes markedly exceeded the potency of cisplatin and carry potential for single-agent therapy of a hard-to-treat type of cancer (multiple myeloma).

Funder

Agentúra na Podporu Výskumu a Vývoja

European Regional Development Fund

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

Ministerstvo Školství, Mládeže a Tělovýchovy

Uniwersytet Jagielloński Collegium Medicum

Univerzita Palackého v Olomouci

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference61 articles.

1. J.Ferlay , M.Ervik , F.Lam , M.Colombet , L.Mery , M.Piñeros , A.Znaor , I.Soerjomataram and F.Bray , Global Cancer Observatory: Cancer Today , International Agency for Research on Cancer , Lyon , 2020 , https://gco.iarc.fr/today , accessed 09/2022

2. The importance of antiangiogenic effect in multiple myeloma treatment

3. The Role of the Bone Marrow Microenvironment in the Pathophysiology of Myeloma and Its Significance in the Development of More Effective Therapies

4. Revisiting IL-6 antagonism in multiple myeloma

5. Pathogenesis beyond the cancer clone(s) in multiple myeloma

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