Microfluidic concurrent assessment of red blood cell adhesion and microcapillary occlusion: potential hemorheological biomarkers in sickle cell disease-Reference-Cited by-同舟云学术

Microfluidic concurrent assessment of red blood cell adhesion and microcapillary occlusion: potential hemorheological biomarkers in sickle cell disease

Published:2023 Issue:2 Volume:2 Page:457-467
ISSN:2635-0998
Container-title:Sensors & Diagnostics
language:en
Short-container-title:Sens. Diagn.

Author:

Man Yuncheng¹^ORCID,Wu Douglas H.¹,An Ran¹^ORCID,Wei Peiran²,Monchamp Karamoja¹³,Goreke Utku¹^ORCID,Sekyonda Zoe⁴,Wulftange William J.⁴^ORCID,Federici Chiara³⁵,Bode Allison¹³,Nayak Lalitha V.³,Little Jane A.⁶,Gurkan Umut A.¹⁴⁷^ORCID

Affiliation:

1. Department of Mechanical and Aerospace Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA

2. Soft Matter Facility, Texas A&M University, College Station, TX, USA

3. Division of Hematology and Oncology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA

4. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA

5. BioChip Labs, Inc., Cleveland, OH, USA

6. Department of Hematology, UNC Blood Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA

7. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA

Abstract

A microfluidic assay integrated with capillary network-inspired microcapillary arrays and endothelial-associated protein functionalization enables concurrent assessment of red blood cell adhesion and microcapillary occlusion.

Funder

National Science Foundation

National Heart and Lung Institute

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SD/D2SD00095D

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