Heterologous expression of the trichostatin gene cluster and functional characterization ofN-methyltransferase TsnB8-Reference-Cited by-同舟云学术

Heterologous expression of the trichostatin gene cluster and functional characterization ofN-methyltransferase TsnB8

Published:2020 Issue:19 Volume:18 Page:3649-3653
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liu Wei¹²³⁴⁵^ORCID,Jannu Vinay Gopal¹²³⁴⁵,Liu Zhiwen¹²³⁴⁵,Zhang Qingbo¹²³⁴⁵,Jiang Xiaodong¹²³⁴⁵,Ma Liang¹²³⁴⁵,Zhang Wenjun¹²³⁴⁵,Zhang Changsheng¹²³⁴⁵^ORCID,Zhu Yiguang¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Tropical Marine Bio-resources and Ecology

2. Guangdong Key Laboratory of Marine Materia Medica

3. Innovation Academy of South China Sea Ecology and Environmental Engineering

4. South China Sea Institute of Oceanology

5. Chinese Academy of Sciences

Abstract

N-Methyltransferase TsnB8 was demonstrated to catalyze successive methyltransfer reactions in the biosynthesis of trichostatin.

Funder

National Key Research and Development Program of China

Chinese Academy of Sciences

National Natural Science Foundation of China

Qingdao National Laboratory for Marine Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00617C

Reference22 articles.

1. Epigenetic modulators from “The Big Blue”: A treasure to fight against cancer

2. A new antifungal antibiotic, trichostatin.

3. Trichostatin C, a glucopyranosyl hydroxamate.

4. A New Trichostatin Derivative, Trichostatin RK, from Streptomyces sp. RK98-A74.

5. JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634

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