Non-covalent modification of thrombolytic agent nattokinase: simultaneous improvement of fibrinolysis activity and enzymatic stability-Reference-Cited by-同舟云学术

Non-covalent modification of thrombolytic agent nattokinase: simultaneous improvement of fibrinolysis activity and enzymatic stability

Published:2014 Issue:52 Volume:4 Page:27422-27429
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Chen Chen¹²³,Duan Haogang¹²³⁴²,Gao Chunmei¹²³,Liu Mingzhu¹²³,Wu Xin'an⁴²³,Wei Yuhui⁴²³,Zhang Xinyu⁵⁶⁷,Liu Zhen⁸⁹¹⁰

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry and Department of Chemistry

2. Lanzhou University

3. Lanzhou 730000, People's Republic of China

4. The First Hospital

5. Department of Polymer and Fiber Engineering

6. Auburn University

7. Auburn, USA

8. The Department of Chemical and Biomolecular Engineering

9. Johns Hopkins University

10. Baltimore, USA

Abstract

Folic acid modified chitosan (CS-FA) was synthesized and applied to modify Nattokinase (NK), a thrombolytic agent, for better fibrinolysis activity and stability. It provides great opportunities in curing cardiovascular disease (CVD), a leading cause of death globally.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA02626H

Reference37 articles.

1. The Relationship Between Metabolic Risk Factors and Incident Cardiovascular Disease in Europeans, South Asians, and African Caribbeans

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3. Coordination of Thrombolytic Pro-Ala-Lys peptides with Cu (II): Leading to Nanoscale Self-assembly, Increase of Thrombolytic Activity and Additional Vasodilation

4. Conjugation of nattokinase and lumbrukinase with magnetic nanoparticles for the assay of their thrombolytic activities

5. Optimization of media composition for Nattokinase production by Bacillus subtilis using response surface methodology

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