Chiral Lewis acid-bonded picolinaldehyde enables enantiodivergent carbonyl catalysis in the Mannich/condensation reaction of glycine ester-Reference-Cited by-同舟云学术

Chiral Lewis acid-bonded picolinaldehyde enables enantiodivergent carbonyl catalysis in the Mannich/condensation reaction of glycine ester

Published:2021 Issue:12 Volume:12 Page:4353-4360
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhong Xia¹²³⁴⁵^ORCID,Zhong Ziwei¹²³⁴⁵^ORCID,Wu Zhikun¹²³⁴⁵^ORCID,Ye Zhen⁶³⁷⁸⁹,Feng Yuxiang⁶³⁷⁸⁹,Dong Shunxi¹²³⁴⁵^ORCID,Liu Xiaohua¹²³⁴⁵^ORCID,Peng Qian⁶³⁷⁸⁹^ORCID,Feng Xiaoming¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Green Chemistry & Technology

2. Ministry of Education

3. College of Chemistry

4. Sichuan University

5. Chengdu 610064

6. State Key Laboratory of Elemento-Organic Chemistry

7. Nankai University

8. Tianjin 300071

9. P. R. China

Abstract

The catalytic asymmetric Mannich/condensation of glycine ester with aldimines was achieved by merging chiral N,N′-dioxide/Yb^III complex Lewis acid catalysis/carbonyl catalysis under mild condition.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Tianjin City

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC07052A

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2. In situ tether formation from amines and alcohols enabling highly selective Tsuji–Trost allylation and olefin functionalization