Corroboration of Zn(ii)–Mg(ii)-tertiary structure interplays essential for the optimal catalysis of a phosphorothiolate thiolesterase ribozyme-Reference-Cited by-同舟云学术

Corroboration of Zn(ii)–Mg(ii)-tertiary structure interplays essential for the optimal catalysis of a phosphorothiolate thiolesterase ribozyme

Published:2018 Issue:57 Volume:8 Page:32775-32793
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Tzu-Pin¹²³⁴⁵^ORCID,Su Yu-Chih¹²³⁴,Chen Yi¹²³⁴,Severance Scott⁶⁷⁸⁹,Hwang Chi-Ching¹⁰²³⁴,Liou Yi-Ming¹²³⁴,Lu Chia-Hui¹²³⁴,Lin Kun-Liang¹²³⁴,Zhu Rui Jing¹²³⁴,Wang Eng-Chi¹²³⁴

Affiliation:

1. Department of Medicinal and Applied Chemistry

2. Kaohsiung Medical University

3. Kaohsiung

4. Taiwan

5. Kaohsiung Medical University Hospital

6. Department of Molecular and Cellular Sciences

7. Liberty University College of Osteopathic Medicine

8. Lynchburg

9. USA

10. Department of Biochemistry

Abstract

Zn(ii) and Mg(ii) and GAGA tetraloop in the ion atmosphere of the TW17 ribozyme is critical to optimal ribozyme catalysis at alkaline pH.

Funder

National Science Council

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA05083J

Reference44 articles.

1. Crawling Out of the RNA World

2. The Evolution of Ribozyme Chemistry

3. Mechanisms of covalent self-assembly of the Azoarcus ribozyme from four fragment oligonucleotides

4. Alternative Roles for Metal Ions in Enzyme Catalysis and the Implications for Ribozyme Chemistry

5. Comparative Enzymology and Structural Biology of RNA Self-Cleavage

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1. 42.16.4 Phosphoric Acid and Derivatives (Update 2021);Knowledge Updates 2021/1;2021