Synthesis of α,ω-polyfluorinated α-amino acid derivatives and δ,δ-difluoronorvaline

Author:

Ulbrich Dirk12345,Daniliuc Constantin G.1234,Haufe Günter12345

Affiliation:

1. Organisch-Chemisches Institut

2. Westfälische Wilhelms-Universität

3. D-48149 Münster

4. Germany

5. Cells-in-Motion Cluster of Excellence

Abstract

Intending to synthesize ω,ω-difluoroalkyl amino acid derivatives by oxidative desulfurization–fluorination reactions of suitable arylthio-2-phthalimido butanoates and pentanoates, in addition to small amounts of the target products, mainly α,ω-polyfluorinated amino acid derivatives were formed by additional sulfur-assisted α-fluorination.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference59 articles.

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2. P. Kirsch , Modern Fluoroorganic Chemistry: Synthesis, Reactivity, Applications, Wiley-VCH, Weinheim, 2013

3. Fluorine and Health - Molecular Imaging, Biomedical Materials and Pharmaceuticals, ed. A. Tressaud and G. Haufe, Elsevier, Amsterdam, 2008

4. Fluorine in Medicinal Chemistry and Chemical Biology, ed. I. Ojima, John Wiley & Sons Ltd, Chichester, 2009

5. J.-P. Bégué and D.Bonnet-Delpon, Bioorganic and Medicinal Chemistry of Fluorine, Imperial College Press, Hoboken, 2008

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