Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties-Reference-Cited by-同舟云学术

Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties

Published:2024 Issue:18 Volume:12 Page:4389-4397
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Xu Yang¹^ORCID,Lin Hao²,Gao Zhe³,Guo Rui³,Kan Yu-chen³,Han Lu-yang³,Bu Wen-han³,Wang Zhi²,Asilebieke Ayakuzi¹,Han Long-xu³,Li Chuang⁴,He Fang²,Chu Jian-jun³⁴

Affiliation:

1. Department of Pharmaceutical Science and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, China

2. Department of Orthopedics, Hefei BOE Hospital, Teaching Hospital of Shanghai University Medical College, Hefei, Anhui 230013, China

3. Department of Orthopedics, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230011, China

4. Institute of Advanced Technology, University of Science and Technology of China, Hefei, Anhui 230000, China

Abstract

A hydrazone-based isoniazid acrylic (HIA) bone cement is reported. It possesses mechanical strength and release properties superior to those of traditional isoniazid-containing antibiotic-loaded bone cement.

Funder

Natural Science Foundation of Anhui Province

University Natural Science Research Project of Anhui Province

Anhui Medical University

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D3TB02661B

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