A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death

Author:

Vigueras Gloria1ORCID,Markova Lenka2ORCID,Novohradsky Vojtech2ORCID,Marco Alicia1ORCID,Cutillas Natalia1ORCID,Kostrhunova Hana2ORCID,Kasparkova Jana2ORCID,Ruiz José1ORCID,Brabec Viktor2ORCID

Affiliation:

1. Departamento de Quimica Inorganica, Universidad de Murcia and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), E-30071 Murcia, Spain

2. Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61265 Brno, Czech Republic

Abstract

The new iridium complex selectively targets cancer stem cells and has potential to induce immunogenic cell death in cancer cells.

Funder

Grantová Agentura České Republiky

Ministerio de Ciencia e Innovación

Universidad de Murcia

Fundación Séneca

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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