Shape-dependent biological activity of spherical and quasi-spherical silver nanoparticles in E. coli, A549 cells and mice

Author:

Puchkova Ludmila V.123ORCID,Sankova Tatiana P.3,Magazenkova Daria N.14ORCID,Skomorokhova Ekaterina A.12,Orlov Iurii A.1,Sakhenberg Elena I.5,Sosnin Ilya M.1,Al Farroukh Mohammad36,Romanov Alexey E.1,Ilyechova Ekaterina Yu.123ORCID

Affiliation:

1. Research center of advanced functional materials and laser communication systems, ADTS Institute, ITMO University, 197101 St. Petersburg, Russia

2. Department of Molecular Genetics, Institute of Experimental Medicine, 197376 St. Petersburg, Russia

3. Institute of Biomedical Systems and Biotechnology, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia

4. Higher School of Fundamental Physical Research, Institute of Physics and Mechanics, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia

5. Laboratory of cell protection mechanisms, Institute of Cytology, RAS, 194064 St. Petersburg, Russia

6. Federal State Budgetary Scientific Institution, Saint Petersburg State University, 199034 St. Petersburg, Russia

Abstract

Quasi-spherical silver nanoparticles (AgNPs) with more edges possessed higher antibacterial activity but the same ability to interfere with copper metabolism in mice as the spherical AgNPs with the same size.

Funder

Russian Foundation for Basic Research

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Environmental Science,Materials Science (miscellaneous)

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