Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum-Reference-Cited by-同舟云学术

Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum

Published:2017 Issue:3 Volume:15 Page:589-597
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Woodland John G.¹²³⁴,Hunter Roger¹²³⁴,Smith Peter J.⁵⁶²⁷⁴,Egan Timothy J.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Cape Town

3. Rondebosch

4. South Africa

5. Division of Clinical Pharmacology

6. Department of Medicine

7. Observatory

Abstract

Preparation of fluorescent analogues of quinine and quinidine reveals their localisation in live malaria parasites using confocal and super-resolution microscopy.

Funder

National Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02110G

Reference36 articles.

1. From Shakespeare to Defoe: Malaria in England in the Little Ice Age

2. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

3. Insights into the Role of Heme in the Mechanism of Action of Antimalarials