Standardized hot water extract from the leaves of Hydrangea serrata (Thunb.) Ser. alleviates obesity via the AMPK pathway and modulation of the gut microbiota composition in high fat diet-induced obese mice

Author:

Han Hee-Soo12345,Lee Hwi-Ho12345,Gil Hyo-Sun12345,Chung Kyung-Sook12345,Kim Jeon-Kyung67345,Kim Dong-Hyun67345ORCID,Yoon Jimin89234,Chung Eun Kyoung89234,Lee Jong Kil92345,Yang Woong Mo1011345ORCID,Shin Yu-Kyong1213145,Ahn Hye Shin1213145,Lee Sun Hee1213145,Lee Kyung-Tae12345ORCID

Affiliation:

1. Department of Pharmaceutical Biochemistry

2. College of Pharmacy

3. Kyung Hee University

4. Seoul

5. Republic of Korea

6. Department of Life and Nanopharmaceutical Sciences

7. Graduate School

8. Division of Clinical Pharmacy

9. Department of Pharmacy

10. Department of Convergence Korean Medical Science

11. College of Korean Medicine

12. Department of New Material Development

13. COSMAXBIO

14. Gyeonggi

Abstract

WHS prevented the HFD-induced obesity via regulating AMPK and AKT/mTOR signaling pathway. WHS might be a potential dietary supplement for alleviating obesity.

Funder

Korea Food Research Institute

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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