Remote C(sp3)–H heteroarylation of N-fluoroarylsulfonamides via a silyl radical process under visible light irradiation

Author:

Hu Ya-Jian1ORCID,Liu Jin-Chang2,Zhang Guang-Yi1,Yuan Ting-Ting1,Wang Shan1,Liang Xiao-Xia1,Lan Ping1ORCID,Jiang Ren-Wang2ORCID,Banwell Martin G.13ORCID,He Yu-Tao1ORCID

Affiliation:

1. Institute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, Guangdong, China

2. State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China

3. Guangdong Key Laboratory for Research and the Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong 524023, China

Abstract

An efficient method for the remote heteroarylation of unactivated C(sp3)–H bonds has been developed involving a silyl radical-mediated relay reaction.

Funder

National Natural Science Foundation of China

Guangzhou Municipal Science and Technology Project

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

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