Differential cellular responses to FDA-approved nanomedicines: an exploration of albumin-based nanocarriers and liposomes in protein corona formation

Author:

Putri Athika Darumas12ORCID,Hsu Ming-Jen3,Han Chia-Li4,Chao Fang-Ching5,Hsu Chun-Hua6ORCID,Lorenz Christian D.7ORCID,Hsieh Chien-Ming18ORCID

Affiliation:

1. School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan

2. Semarang College of Pharmaceutical Sciences (STIFAR), Semarang City, 50192, Indonesia

3. Department of Pharmacology, Taipei Medical University, Taipei, 11031, Taiwan

4. Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan

5. Université Paris-Saclay, CNRS UMR 8612, Institut Galien Paris-Saclay, Châtenay-Malabry, France

6. Department of Agricultural Chemistry, National Taiwan University, Taipei, 10617, Taiwan

7. Biological Physics and Soft Matter Group, Department of Physics, King's College London, London WC2R 2LS, UK

8. Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan

Abstract

Albumin nanoparticles attract less serum protein adsorption than liposomes and hard corona proteins on albumin nanoparticles elicit higher cellular uptake. Coarse-grained molecular simulations reveal the biological mechanism of protein corona.

Funder

Ministry of Science and Technology, Taiwan

National Science and Technology Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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