Enantioselective radical process for synthesis of chiral indolines by metalloradical alkylation of diverse C(sp3)

Enantioselective radical process for synthesis of chiral indolines by metalloradical alkylation of diverse C(sp3)–H bonds

Published:2018 Issue:22 Volume:9 Page:5082-5086
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wen Xin¹²³⁴^ORCID,Wang Yong¹²³⁴^ORCID,Zhang X. Peter¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Merkert Chemistry Center

3. Boston College

4. USA

Abstract

A new C–C bond formation strategy based on enantioselective radical alkylation of C(sp³)–H bonds via Co(ii)-based metalloradical catalysis has been demonstrated for stereoselective synthesis of chiral indolines.

Funder

National Institute of General Medical Sciences

Division of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC01476K

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