Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors
Author:
Affiliation:
1. Department of Chemistry
2. University of York
3. York
4. UK
5. Ferrier Research Institute
6. Victoria University of Wellington
7. Gracefield, Lower Hutt 5010
8. New Zealand
Abstract
Herein we report synthesis of complex heparan sulfate oligosaccharide precursors by automated glycan assembly using disaccharide donor building blocks.
Funder
Biotechnology and Biological Sciences Research Council
Royal Society
Engineering and Physical Sciences Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02756K
Reference38 articles.
1. Heparan Sulfate Biosynthesis
2. The Structure of Glycosaminoglycans and their Interactions with Proteins
3. Heparan sulphate proteoglycans fine-tune mammalian physiology
4. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
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