Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages-Reference-Cited by-同舟云学术

Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages

Published:2017 Issue:27 Volume:53 Page:3842-3845
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Dandela Rambabu¹²³⁴,Mashiach Roi¹²³⁴,Adepu Raju¹²³⁴,Gregor Rachel¹²³⁴,Athamna Muhammad⁵⁶⁷⁸⁴,Zecharia Efrat⁵⁶⁷⁸⁴,Ernst Orna⁵⁶⁷⁸⁴,Zor Tsaffrir⁵⁶⁷⁸⁴,Meijler Michael M.¹²³⁴^ORCID

Affiliation:

1. Dept. of Chemistry and the National Institute for Biotechnology in the Negev

2. Ben-Gurion University of the Negev

3. Be’er Sheva

4. Israel

5. Department of Biochemistry & Molecular Biology

6. Life Sciences Institute

7. Tel-Aviv University

8. Tel-Aviv 69978

Abstract

Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC09849E

Reference31 articles.

1. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

2. Activation of mTOR and RhoA is a major mechanism by which ceramide 1-phosphate stimulates macrophage proliferation

3. New insights on the role of ceramide 1-phosphate in inflammation

4. Ceramide 1-phosphate stimulates glucose uptake in macrophages

5. Innate Immunity as Orchestrator of Bone Marrow Homing for Hematopoietic Stem/Progenitor Cells

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