pH-responsive polyelectrolyte complexation on upconversion nanoparticles: a multifunctional nanocarrier for protection, delivery, and 3D-imaging of therapeutic protein-Reference-Cited by-同舟云学术

pH-responsive polyelectrolyte complexation on upconversion nanoparticles: a multifunctional nanocarrier for protection, delivery, and 3D-imaging of therapeutic protein

Published:2022 Issue:18 Volume:10 Page:3420-3433
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

De Ranjit¹²^ORCID,Song Yo Han¹^ORCID,Mahata Manoj Kumar¹³^ORCID,Lee Kang Taek¹^ORCID

Affiliation:

1. Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, South Korea

2. Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea

3. Drittes Physikalisches Institut – Biophysik, Georg-August-Universität Göttingen, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany

Abstract

The delicate tertiary structure of proteins, their susceptibility to heat- and enzyme-induced irreversible denaturation, and tendency to get accumulated at the cell membrane during uptake are daunting challenges in proteinaceous therapeutic delivery.

Funder

National Research Foundation of Korea

Gwangju Institute of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB00246A

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