Real-time imaging of individual virion-triggered cortical actin dynamics for human immunodeficiency virus entry into resting CD4 T cells

Author:

Yin Wen12345,Li Wei12345,Li Qin12345,Liu Yuanyuan12345,Liu Ji12345,Ren Min12345,Ma Yingxin12345ORCID,Zhang Zhiping12345,Zhang Xiaowei12345,Wu Yuntao678910,Jiang Shibo111213145,Zhang Xian-En15163175ORCID,Cui Zongqiang12345ORCID

Affiliation:

1. State Key Laboratory of Virology

2. Wuhan Institute of Virology

3. Chinese Academy of Sciences

4. Wuhan 430071

5. People's Republic of China

6. National Center for Biodefense and Infectious Diseases

7. Department of Molecular and Microbiology

8. George Mason University

9. Manassas

10. USA

11. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health

12. Shanghai Medical College and Institute of Medical Microbiology

13. Fudan University

14. Shanghai 200032

15. National Laboratory of Biomacromolecules

16. Institute of Biophysics

17. Beijing 100101

Abstract

Using QD-encapsulated HIV particles and single-virus tracking, we revealed virus-regulated cortical actin dynamics during HIV entry into CD4 T cells.

Funder

Chinese Academy of Sciences

National Basic Research Program of China

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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