Unsymmetric N-heterocyclic carbene ligand enabled nickel-catalysed arylation of bulky primary and secondary amines

Author:

Wang Zi-Chao1,Li Yan-Yu2,Zhang Shuo-Qing2ORCID,Hong Xin234ORCID,Shi Shi-Liang1ORCID

Affiliation:

1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

2. Center of Chemistry for Frontier Technologies, Department of Chemistry, State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310027, China

3. Beijing National Laboratory for Molecular Sciences, Zhongguancun North First Street NO. 2, Beijing 100190, PR China

4. Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China

Abstract

A general and efficient Ni-catalysed arylation of bulky primary and secondary amines with aryl chlorides or phenol derivatives is described. DFT studies suggest that unsymmetric bulky and flexible NHC ligand is critical to promote this reaction.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Ningbo

Program of Shanghai Academic Research Leader

Beijing Institute of Genomics, Chinese Academy of Sciences

Zhejiang University

Beijing National Laboratory for Molecular Sciences

Fundamental Research Funds for the Central Universities

State Key Laboratory of Clean Energy Utilization

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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