Molecular rotors report on changes in live cell plasma membrane microviscosity upon interaction with beta-amyloid aggregates

Author:

Kubánková Markéta1234ORCID,López-Duarte Ismael1234ORCID,Kiryushko Darya56748ORCID,Kuimova Marina K.1234ORCID

Affiliation:

1. Department of Chemistry

2. Imperial College London

3. London SW7 2AZ

4. UK

5. Department of Materials and London Center for Nanotechnology

6. Imperial College

7. SW72AZ London

8. Centre for Neuroinflammation and Neurodegeneration

Abstract

Viscosity-sensing fluorophores termed molecular rotors were used to investigate the microviscosity of plasma membranes of live cells upon interaction with oligomeric and fibrillar forms of beta-amyloid Aβ(1–42).

Funder

Engineering and Physical Sciences Research Council

Michael J. Fox Foundation for Parkinson's Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

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